![]() The biomimetic PDMS scaffold was fabricated through spin coating and lithography method. RPEs were cultured on the PDMS-based biomimetic scaffolds and validated the cells gene expression. In this study, we developed an innovative polydimethylsiloxane (PDMS)-based biomimetic scaffolds with cylinder micropillars for the cultivation of induced pluripotent stem cell-derived RPEs (iPSC-RPEs). Cell therapy that possesses enormous potential in regenerative medicine may provide an alternative treatment for several incurable diseases such as AMD. Once the retinal pigment epithelium (RPE) layers are destroyed, the poor visual acuity and recognition are generally irreversible. 229920001690 polydopamine Polymers 0.Age-related macular degeneration (AMD) is one of the leading causes of vision loss.229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 5.230000000149 penetrating Effects 0.000 claims description 5.239000005038 ethylene vinyl acetate Substances 0.000 claims description 5.239000000853 adhesive Substances 0.000 claims description 6.-1 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 8.229920001971 elastomer Polymers 0.000 claims description 9.229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 49.239000004205 dimethyl polysiloxane Substances 0.000 claims description 49.238000011068 load Methods 0.000 claims abstract description 9.239000000835 fiber Substances 0.000 claims abstract description 21.239000000203 mixture Substances 0.000 claims abstract description 53.238000007906 compression Methods 0.000 claims abstract description 55.229960005188 collagen Drugs 0.000 claims abstract description 55. ![]() 229920001436 collagen Polymers 0.000 claims abstract description 55.108010035532 Collagen Proteins 0.000 claims abstract description 57.102000008186 Collagen Human genes 0.000 claims abstract description 57.239000000758 substrate Substances 0.000 claims abstract description 214.238000004519 manufacturing process Methods 0.000 title claims abstract description 23.Assignors: CHO, IL-JOO, LEE, CHANGJOON JUSTIN, CHOI, NAKWON, JEONG, SOHYEON, KIM, SOHYUN, YOON, EUI SUNG Publication of US20170253860A1 publication Critical patent/US20170253860A1/en Application granted granted Critical Publication of US11021586B2 publication Critical patent/US11021586B2/en Status Active legal-status Critical Current Adjusted expiration legal-status Critical Links Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority to KR10-2016-0025885 priority Critical Priority to KR1020160025885A priority patent/KR101850307B1/en Application filed by Korea Advanced Institute of Science and Technology KAIST filed Critical Korea Advanced Institute of Science and Technology KAIST Assigned to KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY reassignment KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Original Assignee Korea Advanced Institute of Science and Technology KAIST Priority date (The priority date is an assumption and is not a legal conclusion. Korea Advanced Institute of Science and Technology KAIST Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) ( en Inventor Nakwon Choi Sohyun KIM Sohyeon JEONG Eui Sung Yoon Changjoon Justin LEE Il-Joo Cho Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Granted Application number US15/438,215 Other versions US11021586B2 Google Patents US20170253860A1 - Apparatus and method for manufacturing channel-coupled scaffold US20170253860A1 - Apparatus and method for manufacturing channel-coupled scaffold
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